The percentage of plasma cells in bone marrow smears, type of immunoglobulin, platelet (Plt), and levels of serum bone metabolic markers and inflammatory factors including alkaline phosphatase (ALP), calcium, phosphate, parathyroid hormone (PTH), beta-isomerized C-telopeptide (β-CTx), vascular endothelial growth factor (VEGF), and interleukin (IL)-6 levels were also recorded. Of the patients with POEMS, 53.7% had thrombocytosis, compared with 1.5% of those with CIDP (P 10 mm) and appearance (osteosclerotic, lytic, mixed). We compared platelet counts in 136 POEMS patients and 67 CIDP controls. Differentiating the 2 entities is crucial, as there are major treatment implications. POEMS ( polyneuropathy, organomegaly, endocrinopathy, monoclonal plasma cell disorder, and skin changes) syndrome may be mistaken for chronic inflammatory demyelinating polyneuropathy (CIDP). Naddaf, Elie Dispenzieri, Angela Mandrekar, Jay Mauermann, Michelle L Thrombocytosis distinguishes POEMS syndrome from chronic inflammatory demyelinating polyneuropathy.
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